Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Molecular Basis of the Versatile Regulatory Mechanism of HtrA-Type Protease AlgW from Pseudomonas aeruginosa

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Li Tao¹²,Song Yingjie¹,Luo Liming³,Zhao Ninglin¹,He Lihui¹,Kang Mei⁴,Li Changcheng¹,Zhu Yibo¹,Shen Yalin¹,Zhao Chang¹,Yang Jing¹,Huang Qin¹,Mou Xingyu¹,Zong Zhiyong¹,Yang Jinliang¹,Tang Hong¹,He Yongxing³,Bao Rui¹

Affiliation:

1. Center of Infectious Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China

2. Department of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, China

3. School of Life Sciences, Lanzhou University, Lanzhou, China

4. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China

Abstract

HtrA-family proteases are commonly employed to sense the protein folding stress and activate the regulated intramembrane proteolysis (RIP) cascade in Gram-negative bacteria. Here, we reveal the unique dual-signal activation and dynamic regulation properties of AlgW, an HtrA-type protease triggering the AlgU stress-response pathway, which controls alginate production and mucoid conversion in Pseudomonas aeruginosa .

Funder

National Key Research and Development Plan

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

National Mega-project for Innovative Drugs

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03299-20

Reference42 articles.