<i>Toxoplasma</i> IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression-Reference-Cited by-同舟云学术

Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hashizaki Emi¹,Sasai Miwa¹²³^ORCID,Okuzaki Daisuke⁴^ORCID,Nishi Tsubasa⁵,Kobayashi Takashi⁶,Iwanaga Shiroh⁷,Yamamoto Masahiro¹²³^ORCID

Affiliation:

1. Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

2. Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

3. Department of Immunoparasitology, Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan

4. Genome Information Research Center, Osaka University, Suita, Osaka, Japan

5. Department of Medical Zoology, Faculty of Medicine, Mie University, Mie, Japan

6. Infectious Disease Control, Faculty of Medicine, Research Center for Global and Local Infectious Diseases, Oita University, Oita, Japan

7. Department of Molecular Parasitology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Abstract

The parasite Toxoplasma gondii has a counterdefense system against interferon-γ (IFN-γ)-dependent host immunity which relies on the secretion of parasite effector proteins. ROP18 is one of the effector, which is released into host cells to inactivate IFN-γ-dependent anti- Toxoplasma host proteins. The mechanism by which Toxoplasma ROP18 subverts host immunity has been extensively analyzed, but how Toxoplasma produces this virulence factor remains unclear.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03256-22

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