Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex-Reference-Cited by-同舟云学术

Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Liu Lu¹²,Weber Axel³,Linne Uwe⁴,Shehata Mahmoud²⁵,Pleschka Stephan²⁶,Kracht Michael³,Schmitz M. Lienhard¹^ORCID

Affiliation:

1. Institute of Biochemistry, Justus-Liebig-University, Giessen, Germany

2. Institute of Medical Virology, Justus Liebig University, Giessen, Germany

3. Rudolf-Buchheim-Institute of Pharmacology, Justus-Liebig-University, Giessen, Germany

4. Mass Spectrometry Facility, Department of Chemistry, Philipps University, Marburg, Germany

5. Center of Scientific Excellence for Influenza Viruses, National Research Centre, Cairo, Egypt

6. German Center for Infection Research, Partner Site Giessen, Giessen, Germany

Abstract

Influenza viruses pose a major threat to human health and cause annual epidemics and occasional pandemics. Many virus-encoded proteins exert various functions in different subcellular compartments, as exemplified by the M1 protein, but the molecular mechanisms endowing the multiplicity of functions remain incompletely understood.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03231-22

Reference74 articles.

1. Virulence determinants of pandemic influenza viruses

2. Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement

3. Influenza

4. Influenza virus M1 protein binds to RNA through its nuclear localization signal.

5. Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virions

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unveiling the role of host kinases at different steps of influenza A virus life cycle;Journal of Virology;2024-01-23

2. Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice;Virologica Sinica;2023-12

3. Pathogenicity and virulence of influenza;Virulence;2023-06-20