Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague-Reference-Cited by-同舟云学术

Combinatorial Viral Vector-Based and Live Attenuated Vaccines without an Adjuvant to Generate Broader Immune Responses to Effectively Combat Pneumonic Plague

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kilgore Paul B.¹,Sha Jian¹²,Hendrix Emily K.¹,Motin Vladimir L.¹²³⁴⁵,Chopra Ashok K.¹²⁴⁵

Affiliation:

1. Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA

2. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

3. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

4. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA

5. Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Yersinia pestis , the causative agent of plague, is a Tier-1 select agent and a reemerging human pathogen. A 2017 outbreak in Madagascar with >75% of cases being pneumonic and 8.6% causalities emphasized the importance of the disease.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Technology Commercialization Program, UTMB

John S. Dunn Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03223-21

Reference67 articles.

1. Yersinia pestis--etiologic agent of plague