Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging-Reference-Cited by-同舟云学术

Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Duchon Alice¹,Santos Steven¹,Chen Jianbo¹,Brown Matthew¹,Nikolaitchik Olga A.¹,Tai Sheldon¹,Chao Jeffrey A.²,Freed Eric O.³,Pathak Vinay K.⁴,Hu Wei-Shau¹^ORCID

Affiliation:

1. Viral Recombination Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA

2. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

3. Virus-Cell Interaction Section, National Cancer Institute, Frederick, Maryland, USA

4. Viral Mutation Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA

Abstract

To generate infectious virions, HIV-1 must package its full-length RNA as the genome during particle assembly. HIV-1 Gag:RNA interactions mediate genome packaging, but the mechanism remains unclear.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03254-21

Reference44 articles.

1. HIV-1 assembly, release and maturation

2. Life of psi: How full-length HIV-1 RNAs become packaged genomes in the viral particles

3. RNA Packaging in HIV