STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk-Reference-Cited by-同舟云学术

STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wang Chenyao¹^ORCID,Sharma Nikhil¹,Veleeparambil Manoj¹,Kessler Patricia M.¹,Willard Belinda¹,Sen Ganes C.¹

Affiliation:

1. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

The innate immune response to virus infection leads to interferon production and inhibition of viral replication. STING, an ER-bound protein, mediates such a response to cytoplasmic cellular or microbial DNA.

Funder

HHS | NIH | National Cancer Institute

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03228-21

Reference40 articles.

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2. STING: infection, inflammation and cancer

3. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

4. STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

5. A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

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