A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum-Reference-Cited by-同舟云学术

A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mukherjee Angana¹^ORCID,Crochetière Marie-Ève¹²,Sergerie Audrey¹²,Amiar Souad³,Thompson L. Alexa⁴^ORCID,Ebrahimzadeh Zeinab¹²,Gagnon Dominic¹,Lauruol Florian¹²,Bourgeois Alexandra¹²,Galaup Thomas¹²,Roucheray Stéphanie¹²,Hallée Stéphanie¹²,Padmanabhan Prasad K.⁵,Stahelin Robert V.³,Dacks Joel B.⁴⁶,Richard Dave¹²^ORCID

Affiliation:

1. Centre de Recherche en Infectiologie, CRCHU de Québec-Université Laval, Laurier Québec (QC), Canada

2. Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City (Qc), Canada

3. Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA

4. Division of Infectious Disease, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

5. Boler-Parseghian Center for Rare and Neglected Diseases, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA

6. Institute of Parasitology, Biology Center, CAS, Ceske Budejovice, Czech Republic

Abstract

Malaria represents an enormous burden for a significant proportion of humanity and the lack of vaccines and problems with drug resistance to all antimalarials demonstrate the need to develop new therapeutics. Inhibitors of phosphoinositide metabolism are currently being developed as antimalarials but our understanding of this biological pathway is incomplete.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03239-21

Reference139 articles.

1. WHO. 2012. World malaria report. WHO, Geneva, Switzerland.

2. Evidence of Artemisinin-Resistant Malaria in Western Cambodia