Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound-Reference-Cited by-同舟云学术

Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hefnawy Aya¹,Negreira Gabriel¹,Jara Marlene¹,Cotton James A.²,Maes Ilse¹,D’Haenens Erika¹,Imamura Hideo¹,Cuypers Bart¹^ORCID,Monsieurs Pieter¹,Mouchtoglou Christina¹,De Winter Hans³,Pintelon Isabel⁴,Timmermans Jean-Pierre⁴,Berriman Matt²,Sanders Mandy²,Martin Julio⁵,de Muylder Geraldine¹,Dujardin Jean-Claude¹⁶^ORCID,Sterckx Yann G.-J.⁷⁸,Domagalska Malgorzata Anna¹

Affiliation:

1. Molecular Parasitology Unit, Institute of Tropical Medicine, Antwerp, Belgium

2. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom

3. Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium

4. Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium

5. Global Health R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain

6. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

7. Laboratory of Medical Biochemistry, University of Antwerp, Antwerp, Belgium

8. Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium

Abstract

Humans and their pathogens are continuously locked in a molecular arms race during which the eventual emergence of pathogen drug resistance (DR) seems inevitable. For neglected tropical diseases (NTDs), DR is generally studied retrospectively once it has already been established in clinical settings.

Funder

European Commission

Fonds Wetenschappelijk Onderzoek

Wellcome Trust Sanger Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03264-21

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1. Alice in microbes' land: adaptations and counter-adaptations of vector-borne parasitic protozoa and their hosts