Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

Author:

Saha Sudeshna123ORCID,Coady Alison14,Sasmal Aniruddha123,Kawanishi Kunio123ORCID,Choudhury Biswa1,Yu Hai5ORCID,Sorensen Ricardo U.6,Inostroza Jaime7,Schoenhofen Ian C.8,Chen Xi5ORCID,Münster-Kühnel Anja9,Sato Chihiro10,Kitajima Ken10,Ram Sanjay11,Nizet Victor14ORCID,Varki Ajit123ORCID

Affiliation:

1. Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA

2. Center for Academic Research and Training in Anthropogeny, University of California, San Diego, La Jolla, California, USA

3. Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, California, USA

4. Department of Pediatrics, University of California, San Diego, La Jolla, California, USA

5. Department of Chemistry, University of California, Davis, California, USA

6. Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

7. Department of Basic Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile

8. Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, Ontario, Canada

9. Clinical Biochemistry, Hannover Medical School, Hannover, Germany

10. Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan

11. Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Abstract

All cells in vertebrates are coated with a dense array of glycans often capped with sugars called sialic acids. Sialic acids have many functions, including serving as a signal for recognition of “self” cells by the immune system, thereby guiding an appropriate immune response against foreign “nonself” and/or damaged cells.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference135 articles.

1. Varki A, Schnaar RL, Schauer R. 2017. Sialic acids and other nonulosonic acids. In Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH (ed), Essentials of glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

2. Unified Theory of Bacterial Sialometabolism: How and Why Bacteria Metabolize Host Sialic Acids

3. A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs.

4. The distribution of sialic acids in nature

5. Green algaeChlamydomonas reinhardtiipossess endogenous sialylated N-glycans

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