Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States

Abstract

ABSTRACTWe sequenced the full lengths of thegyrA,gyrB,parC, andparEgenes in 13 fluoroquinolone-resistantUreaplasmaisolates (levofloxacin MICs, 4 to 32 μg/ml) and 10 susceptible isolates (MICs ≤ 2 μg/ml). Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected.