Lichtheimia corymbifera Colonization Leading to Pulmonary Infection Can Be Prevented with Liposomal Amphotericin B in a New Murine Model

Author:

Brunet Thomas12,Brunet Kévin123,Jouvion Grégory4,Cateau Estelle3,Marchand Sandrine125ORCID,Rammaert Blandine126ORCID

Affiliation:

1. INSERM U1070, Poitiers, France

2. Faculté de Médecine et Pharmacie, Univ Poitiers, Poitiers, France

3. Unité de Mycologie-Parasitologie, Département des Agents Infectieux, CHU Poitiers, Poitiers, France

4. Unité de Neuropathologie Expérimentale, Institut Pasteur, Paris, France

5. Laboratoire de Toxicologie-Pharmacocinétique, CHU Poitiers, Poitiers, France

6. Service de Maladies Infectieuses et Tropicales, CHU Poitiers, Poitiers, France

Abstract

The incidence of pulmonary mucormycosis is constantly increasing, especially in hematological patients staying in high-efficiency particulate air-filtered rooms. Pulmonary inhalation of spores may occur outside the hospital, leading to invasive disease once patients received chemotherapies.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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