Author:
Lu Yanhui,Celum Connie,Wald Anna,Baeten Jared M.,Cowan Frances,Delany-Moretlwe Sinead,Reid Stewart E.,Hughes James P.,Wilcox Ellen,Corey Lawrence,Hendrix Craig W.
Abstract
ABSTRACTAcyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
19 articles.
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