Fluconazole Penetration into the Pancreas-Reference-Cited by-同舟云学术

Fluconazole Penetration into the Pancreas

Published:2000-09 Issue:9 Volume:44 Page:2569-2571
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shrikhande Shailesh¹,Friess Helmut¹,Issenegger Claudia¹,Martignoni Marcus E.¹,Yong Huang¹,Gloor Beat¹,Yeates Rodney²,Kleeff Jörg¹,Büchler Markus W.¹

Affiliation:

1. Department of Visceral and Transplantation Surgery, University of Bern, Bern, Switzerland,1and

2. Pfizer Mack Research Laboratory, Illertissen, Germany2

Abstract

ABSTRACT Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 ± 3.38 μg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.9.2569-2571.2000

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