Bacterial and Clinical Characteristics of Health Care- and Community-Acquired Bloodstream Infections Due to Pseudomonas aeruginosa

Abstract

ABSTRACTHealth care-associated infections, includingPseudomonas aeruginosabloodstream infection, have been linked to delays in appropriate antibiotic therapy and an increased mortality rate. The objective of this study was to evaluate intrinsic virulence, bacterial resistance, and clinical outcomes of health care-associated bloodstream infections (HCABSIs) in comparison with those of community-acquired bloodstream infections (CABSIs) caused byP. aeruginosa. We conducted a retrospective multicenter study of consecutiveP. aeruginosabacteremia patients at two university-affiliated hospitals. Demographic, clinical, and treatment data were collected. Microbiologic analyses includedin vitrosusceptibility profiles and type III secretory (TTS) phenotypes. Sixty CABSI and 90 HCABSI episodes were analyzed. Patients with HCABSIs had more organ dysfunction at the time of bacteremia (P= 0.05) and were more likely to have been exposed to antimicrobial therapy (P< 0.001) than those with CABSIs. Ninety-two percent of the carbapenem-resistantP. aeruginosainfections were characterized as HCABSIs. The 30-day mortality rate for CABSIs was 26% versus 36% for HCABSIs (P= 0.38). The sequential organ failure assessment score at the time of bacteremia (hazard ratio [HR], 1.2; 95% confidence interval [CI], 1.1 to 1.3) and the TTS phenotype (HR 2.1; 95% CI, 1.1 to 3.9) were found to be independent predictors of the 30-day mortality rate. No mortality rate difference was observed between CABSIs and HCABSIs caused byP. aeruginosa. Severity of illness and expression of TTS proteins were the strongest predictors of the 30-day mortality rate due toP. aeruginosabacteremia. FutureP. aeruginosabacteremia trials designed to neutralize TTS proteins are warranted.