Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience

Author:

Lopatto David1,Rosenwald Anne G.2,DiAngelo Justin R.3,Hark Amy T.4,Skerritt Matthew5,Wawersik Matthew6,Allen Anna K.7,Alvarez Consuelo8,Anderson Sara9,Arrigo Cindy10,Arsham Andrew11,Barnard Daron12,Bazinet Christopher13,Bedard James E. J.14,Bose Indrani15,Braverman John M.16,Burg Martin G.17,Burgess Rebecca C.18,Croonquist Paula19,Du Chunguang20,Dubowsky Sondra21,Eisler Heather22,Escobar Matthew A.23,Foulk Michael24,Furbee Emily25,Giarla Thomas26,Glaser Rivka L.18,Goodman Anya L.27,Gosser Yuying28,Haberman Adam29,Hauser Charles30,Hays Shan31,Howell Carina E.32,Jemc Jennifer33,Johnson M. Logan34,Jones Christopher J.35,Kadlec Lisa36,Kagey Jacob D.37,Keller Kimberly L.38,Kennell Jennifer39,Key S. Catherine Silver40,Kleinschmit Adam J.41,Kleinschmit Melissa41,Kokan Nighat P.42,Kopp Olga Ruiz43,Laakso Meg M.44,Leatherman Judith45,Long Lindsey J.46,Manier Mollie47,Martinez-Cruzado Juan C.48,Matos Luis F.49,McClellan Amie Jo50,McNeil Gerard51,Merkhofer Evan52,Mingo Vida53,Mistry Hemlata54,Mitchell Elizabeth21,Mortimer Nathan T.55,Mukhopadhyay Debaditya56,Myka Jennifer Leigh57,Nagengast Alexis58,Overvoorde Paul59,Paetkau Don60,Paliulis Leocadia61,Parrish Susan62,Preuss Mary Lai63,Price James V.43,Pullen Nicholas A.45,Reinke Catherine64,Revie Dennis65,Robic Srebrenka66,Roecklein-Canfield Jennifer A.67,Rubin Michael R.68,Sadikot Takrima69,Sanford Jamie Siders70,Santisteban Maria71,Saville Kenneth72,Schroeder Stephanie63,Shaffer Christopher D.73,Sharif Karim A.74,Sklensky Diane E.75,Small Chiyedza76,Smith Mary77,Smith Sheryl78,Spokony Rebecca79,Sreenivasan Aparna80,Stamm Joyce81,Sterne-Marr Rachel26,Teeter Katherine C.82,Thackeray Justin83,Thompson Jeffrey S.84,Peters Stephanie Toering85,Van Stry Melanie75,Velazquez-Ulloa Norma86,Wolfe Cindy87,Youngblom James88,Yowler Brian89,Zhou Leming90,Brennan Janie91,Buhler Jeremy92,Leung Wilson73,Reed Laura K.93,Elgin Sarah C. R.73

Affiliation:

1. Center for Teaching, Learning and Assessment, Grinnell College, Grinnell, IA 50112, USA

2. Biology, Georgetown University, Washington, DC 20057, USA

3. Division of Science, Penn State Berks, Reading, PA 19610, USA

4. Biology, Muhlenberg College, Allentown, PA 18104, USA

5. Science, SUNY Corning Community College, Corning, NY 14830, USA

6. Biology, College of William and Mary, Williamsburg, VA 23187, USA

7. Biology, Howard University, Washington, DC 20059, USA

8. Biology, Longwood University, Farmville, VA 23909, USA

9. Biosciences, Minnesota State University Moorhead, Moorhead, MN 56563, USA

10. Biology, New Jersey City University, Jersey City, NJ 07305, USA

11. Biology, Bemidji State University, Bemidji, MN 56601, USA

12. Biology, Worcester State University, Worcester, MA 01602, USA

13. Biological Sciences, St. John’s University, Queens, NY 11439, USA

14. Biology, University of the Fraser Valley, Abbotsford, BC, V2S 7M8, Canada

15. Biology, Western Carolina University, Cullowhee, NC 28723, USA

16. Biology, Saint Joseph’s University, Philadelphia, PA 19131, USA

17. Biomedical Sciences and Cell & Molecular Biology, Grand Valley State University, Allendale, MI 49401, USA

18. Biological Sciences, Stevenson University, Owings Mills, MD 21117, USA

19. Biology, Anoka-Ramsey Community College, Coon Rapids, MN 55433, USA

20. Biology, Montclair State University, Montclair, NJ 07043, USA

21. Biology, McLennan Community College, Waco, TX 76708, USA

22. Biology, University of the Cumberlands, Williamsburg, KY 40769, USA

23. Biological Sciences, California State University San Marcos, CA 92096, USA

24. Biology, Mercyhurst University, Erie, PA 16546, USA

25. Biology, Washington and Jefferson College, Washington, PA 15301, USA

26. Biology, Siena College, Loudonville, NY 12211, USA

27. Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, CA 93407, USA

28. Student Research and Scholarship, City College CUNY, New York, NY 10031, USA

29. Biology, University of San Diego, San Diego, CA 92110, USA

30. Biology, St. Edward’s University, Austin, TX 78704, USA

31. Biology, Western Colorado University, Gunnison, CO 81231, USA

32. Biological Sciences, Lock Haven University, Lock Haven, PA 17745, USA

33. Biology, Loyola University Chicago, Chicago, IL 60660, USA

34. Biology, Notre Dame College, South Euclid, OH 44121, USA

35. Biological Sciences, Moravian College, Bethlehem, PA 18018, USA

36. Biology, Wilkes University, Wilkes-Barre, PA 18766, USA

37. Biology, University of Detroit Mercy, Detroit, MI 48221, USA

38. Biology, William Woods University, Fulton, MO 65251, USA

39. Biology, Vassar College, Poughkeepsie, NY 12604, USA

40. Biological and Biomedical Sciences, North Carolina Central University, Durham, NC 27707, USA

41. Natural and Applied Science, University of Dubuque, Dubuque, IA 52001, USA

42. Natural Sciences, Cardinal Stritch University, Milwaukee, WI 53217, USA

43. Biology, Utah Valley University, Orem, UT 84058, USA

44. Biology, Eastern University, St. Davids, PA 19087, USA

45. Biological Sciences, University of Northern Colorado, Greeley, CO 80639, USA

46. Biology, Oklahoma Christian University, Oklahoma City, OK 73136, USA

47. Biological Sciences, George Washington University, Washington, DC 20052, USA

48. Biología, University of Puerto Rico at Mayagüez, Mayagüez, PR 00680, USA

49. Biology, Eastern Washington University, Cheney, WA 99004, USA

50. Science and Mathematics, Bennington College, Bennington, VT 05201, USA

51. Biology, York College / CUNY, Jamaica, NY 11451, USA

52. Natural Sciences, Mount Saint Mary College, Newbergh, NY 12550, USA

53. Biology, Columbia College, Columbia, SC 29203, USA

54. Biology and Biochemistry, Widener University, Chester, PA 19013, USA

55. Biological Sciences, Illinois State University, Normal, IL 61790, USA

56. Molecular Biology, Biochemistry, and Bioinformatics, Towson University, Towson, MD 21252, USA

57. Biology, Gateway Community and Technical College, Florence, KY 41042, USA

58. Chemistry and Biochemistry, Widener University, Chester, PA 19013, USA

59. Biology, Macalester College, St. Paul, MN 55105, USA

60. Biology, Saint Mary’s College, Notre Dame, IN 46556, USA

61. Biology, Bucknell University, Lewisburg, PA 17837, USA

62. Biology, McDaniel College, Westminster, MD 21157, USA

63. Biological Sciences, Webster University, St. Louis, MO 63119, USA

64. Biology, Linfield College, McMinnville, OR 97128, USA

65. Biology, California Lutheran University, Thousand Oaks, CA 91360, USA

66. Biology, Agnes Scott College, Decatur, GA 30030, USA

67. Chemistry, Simmons College, Boston, MA 02115, USA

68. Biology, University of Puerto Rico at Cayey, Cayey, PR 00736, USA

69. Biology, Washburn University, Topeka, KS 66621, USA

70. Biology, Ohio Northern University, Ada, OH 45810, USA

71. Biology, University of North Carolina at Pembroke, Pembroke, NC 28372, USA

72. Biology, Albion College, Albion, MI 49224, USA

73. Biology, Washington University in St. Louis, St. Louis, MO 63130, USA

74. Biology, Massasoit Community College, Brockton, MA 02302, USA

75. Biology, Lane College, Jackson, TN 38301, USA

76. Biology, Medgar Evers College, CUNY, Brooklyn, NY 11225, USA

77. Biology, North Carolina A & T State University, Greensboro, NC 27411, USA

78. Biology, Arcadia, University, Glenside, PA 19038, USA

79. Natural Sciences, Baruch College, CUNY, New York, NY 10010, USA

80. Biology, School of Natural Sciences, California State University, Monterey Bay, Seaside, CA 93950, USA

81. Biology, University of Evansville, Evansville, IN 47722, USA

82. Biology, Northern Michigan University, Marquette, MI 49855, USA

83. Biology, Clark University, Worcester, MA 01610, USA

84. Biology, Denison University, Granville, OH 43023, USA

85. Biology, Wartburg College, Waverly, IA 50677, USA

86. Biology, Lewis & Clark College, Portland, OR 97219, USA

87. Biology, Kentucky Wesleyan College, Owensboro, KY 42301, USA

88. Biological Sciences, California State University Stanislaus, Turlock, CA 95382, USA

89. Biology, Grove City College, Grove City, PA 16127, USA

90. Health Information Management, University of Pittsburgh, Pittsburgh, PA 15213, USA

91. Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA

92. Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA

93. Biological Sciences, University of Alabama Tuscaloosa, AL 35487, USA

Abstract

A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) is a consortium of faculty who engage their students in a genomics Course-Based Undergraduate Research Experience (CURE). Students participate in genome annotation, generating gene models using multiple lines of experimental evidence. Our observations suggested that the students’ learning experience is continuous and recursive, frequently beginning with frustration but eventually leading to success as they come up with defendable gene models. In order to explore our “formative frustration” hypothesis, we gathered data from faculty via a survey, and from students via both a general survey and a set of student focus groups. Upon analyzing these data, we found that all three datasets mentioned frustration and struggle, as well as learning and better understanding of the scientific process. Bioinformatics projects are particularly well suited to the process of iteration and refinement because iterations can be performed quickly and are inexpensive in both time and money. Based on these findings, we suggest that a dynamic of “formative frustration” is an important aspect for a successful CURE.

Publisher

American Society for Microbiology

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Education

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