Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli-Reference-Cited by-同舟云学术

Mutational analysis of the feedback sites of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase of Escherichia coli

Published:1997-02 Issue:2 Volume:63 Page:761-762
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Kikuchi Y¹,Tsujimoto K¹,Kurahashi O¹

Affiliation:

1. Central Research Laboratory, Ajinomoto Co., Inc., Kawasaki, Japan. lt_kikuchi@te10.ajinomoto.co.jp

Abstract

In Escherichia coli, aroF, aroG, and aroH encode 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isozymes that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. In vitro chemical mutagenesis of the cloned aroG gene was used to identify residues and regions of the polypeptide essential for phenylalanine feedback inhibition.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.63.2.761-762.1997

Reference12 articles.

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4. The nucleotide sequence of aroG, the gene for 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (phe) in Escherichia coli K-12;Davis W. D.;Nucleic Acids Res.,1982

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