Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy-Reference-Cited by-同舟云学术

Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy

Published:2020-05-26 Issue:6 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sandlund Johanna¹,Davies Kerrie²,Wilcox Mark H.²

Affiliation:

1. Fluxus, Inc., Santa Clara, California, USA

2. Healthcare Associated Infections Research Group, Leeds Teaching Hospitals NHS Trust and University of Leeds, Leeds, United Kingdom

Abstract

Currently available diagnostic tests for Clostridioides difficile infection (CDI) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing algorithms. Ultrasensitive assays for detection of C. difficile toxins provide measurements of disease-specific markers at very low concentrations. These assays may show improved accuracy compared to that of current testing methods and offer a potential standalone solution for CDI diagnosis, although large studies of clinical performance and accuracy are lacking.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01913-19

Reference51 articles.

1. Multistate Point-Prevalence Survey of Health Care–Associated Infections

2. Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study

3. Global burden of Clostridium difficile infections: a systematic review and meta-analysis

4. Antibiotic resistance threats in the United States, 2019

5. Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection

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