Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile-Reference-Cited by-同舟云学术

Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile

Published:2019-03 Issue:3 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hartley-Tassell Lauren E.¹,Awad Milena M.²,Seib Kate L.¹^ORCID,Scarselli Maria³,Savino Silvana³,Tiralongo Joe¹,Lyras Dena²^ORCID,Day Christopher J.¹,Jennings Michael P.¹

Affiliation:

1. Institute for Glycomics, Griffith University, Gold Coast, Australia

2. Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia

3. GSK Vaccines, Siena, Italy

Abstract

Clostridium difficile is a major cause of hospital-acquired antibiotic-associated diarrhea. C. difficile produces two cytotoxins, TcdA and TcdB; both toxins are multidomain proteins that lead to cytotoxicity through the modification and inactivation of small GTPases of the Rho/Rac family.

Funder

Queensland Government

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00676-18

Reference37 articles.

1. Increasing incidence of Clostridium difficile infection, Australia, 2011–2012

2. Epidemiology of Clostridium difficile Infection