Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia-Reference-Cited by-同舟云学术

Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia

Published:2019-08-15 Issue:16 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Davuluri Gangarao¹,Giusto Michela¹,Chandel Rajeev¹,Welch Nicole¹,Alsabbagh Khaled¹,Kant Sashi¹,Kumar Avinash¹,Kim Adam¹,Gangadhariah Mahesha¹,Ghosh Prabar K.²,Tran Uyen²,Krajcik Daniel M.²,Vasu Kommireddy²^ORCID,DiDonato Anthony J.²,DiDonato Joseph A.²,Willard Belinda³,Monga Satdarshan P.⁴⁵,Wang Yuxin⁶,Fox Paul L.²,Stark George R.⁶,Wessely Oliver²,Esser Karyn A.⁷,Dasarathy Srinivasan¹⁸^ORCID

Affiliation:

1. Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA

2. Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA

3. Proteomics Research Core Services, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

4. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

6. Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

7. Department of Physiology and Functional Genomics, Institute of Myology, University of Florida, Gainesville, Florida, USA

8. Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational capacity.

Funder

National Institutes of Health

Mikati Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00451-18

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1. Eukaryotic ribosome biogenesis at a glance