Impaired Ribosomal Biogenesis by Noncanonical Degradation of β-Catenin during Hyperammonemia

Author:

Davuluri Gangarao1,Giusto Michela1,Chandel Rajeev1,Welch Nicole1,Alsabbagh Khaled1,Kant Sashi1,Kumar Avinash1,Kim Adam1,Gangadhariah Mahesha1,Ghosh Prabar K.2,Tran Uyen2,Krajcik Daniel M.2,Vasu Kommireddy2ORCID,DiDonato Anthony J.2,DiDonato Joseph A.2,Willard Belinda3,Monga Satdarshan P.45,Wang Yuxin6,Fox Paul L.2,Stark George R.6,Wessely Oliver2,Esser Karyn A.7,Dasarathy Srinivasan18ORCID

Affiliation:

1. Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio, USA

2. Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA

3. Proteomics Research Core Services, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

4. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

6. Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA

7. Department of Physiology and Functional Genomics, Institute of Myology, University of Florida, Gainesville, Florida, USA

8. Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

Increased ribosomal biogenesis occurs during tissue hypertrophy, but whether ribosomal biogenesis is impaired during atrophy is not known. We show that hyperammonemia, which occurs in diverse chronic disorders, impairs protein synthesis as a result of decreased ribosomal content and translational capacity.

Funder

National Institutes of Health

Mikati Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

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