Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum-Reference-Cited by-同舟云学术

Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum

Published:2022-04-19 Issue:4 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kano Rui¹²^ORCID,Kimura Utako³,Noguchi Hiromitsu⁴⁵,Hiruma Masataro⁵

Affiliation:

1. Department of Veterinary Dermatology, Nihon University College of Bioresource Sciences, Fujisawa, Kanagawa, Japan

2. Teikyo University Institute of Medical Mycology (TIMM), Hachioji, Tokyo, Japan

3. Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan

4. Ochanomizu Institute for Medical Mycology and Allergology, Toshima-ku, Tokyo, Japan

5. Noguchi Dermatology Clinic, Kamimashiki-gun, Kumamoto, Japan

Abstract

The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase ( SQLE ) gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02393-21

Reference14 articles.

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2. Reiss E, Shadomy HJ, Lyon I. 2012. Dermatophytosis, p 527–566. In Fundamental medical mycology, Wiley-Blackwell, Hoboken, NJ.

3. Onychomycosis

4. Amino Acid Substitution in Trichophyton rubrum Squalene Epoxidase Associated with Resistance to Terbinafine

5. Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene

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