Major Group-Specific Protein of Rat Type C Viruses-Reference-Cited by-同舟云学术

Major Group-Specific Protein of Rat Type C Viruses

Published:1972-10 Issue:4 Volume:10 Page:746-750
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Oroszlan S.¹²,Bova D.¹²,Huebner R. J.¹²,Gilden R. V.¹²

Affiliation:

1. Flow Laboratories, Inc., Rockville, Maryland 20852

2. Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The major internal protein of a rat type C virus pseudotype of murine sarcoma virus, MSV(RaLV), was purified by isoelectric focusing (pI = 8.6) and used to prepare antibody in guinea pigs. The protein was identified by its reaction with antisera reactive with the mammalian type C virus group-specific (gs) antigenic determinant, gs-3. The guinea pig antisera mainly contained species-specific (gs-1) antibody for reactions in gel diffusion with other type C viruses were limited to those of rat origin, whereas in complement fixation tests heterologous reactions could be eliminated by use of appropriate antiserum concentrations without affecting homologous reactions. Guinea pig antisera against mouse, hamster, or cat gs-1 determinants did not react with MSV(RaLV) purified gs protein or with any of several other rat type C viruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.10.4.746-750.1972

Reference20 articles.

1. Isolation of a rat-tropic helper virus from M-MSV-O stocks;Aaronson S. A.;Virology,1971

2. Virus particles in a transplantable rat mammary tumor of spontaneous origin;Chopra H. C.;Eur. J. Cancer.,1970

3. Shared viral antigen of mammalian leukemia viruses;Geering G.;Nature (London),1970

4. Group-specific antigens of RNA tumor viruses as markers for subinfectious expression of the RNA virus genome;Gilden R. V.;Proc. Nat. Acad. Sci. U.S.A.,1972

5. Antigenic differentiation of M-MSV(O) from mouse, hamster, and cat C-type viruses;Gilden R. V.;Virology.,1971

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