Size variation of the major immunodominant protein of Cowdria ruminantium-Reference-Cited by-同舟云学术

Size variation of the major immunodominant protein of Cowdria ruminantium

Published:1994-11 Issue:6 Volume:1 Page:744-746
ISSN:1071-412X
Container-title:Clinical Diagnostic Laboratory Immunology
language:en
Short-container-title:Clin Diagn Lab Immunol

Author:

Barbet A F¹,Semu S M¹,Chigagure N¹,Kelly P J¹,Jongejan F¹,Mahan S M¹

Affiliation:

1. Department of Infectious Diseases, University of Florida, Gainesville 32611-0880, USA.

Abstract

An immunodominant response is made to a polypeptide of approximately 32 kDa in animals infected with the rickettsial pathogen Cowdria ruminantium. We show here using cultured strains of the rickettsia from different geographical areas that the apparent size of this polypeptide varies with strain origin. Changes in the primary structure between strains should be considered in the design of vaccines and diagnostic tests based on this antigen.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

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