Mycobactericidal Effects of Different Regimens Measured by Molecular Bacterial Load Assay among People Treated for Multidrug-Resistant Tuberculosis in Tanzania-Reference-Cited by-同舟云学术

Mycobactericidal Effects of Different Regimens Measured by Molecular Bacterial Load Assay among People Treated for Multidrug-Resistant Tuberculosis in Tanzania

Published:2021-03-19 Issue:4 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Mbelele Peter M.¹²^ORCID,Mpolya Emmanuel A.²,Sauli Elingarami²,Mtafya Bariki³,Ntinginya Nyanda E.³,Addo Kennedy K.⁴,Kreppel Katharina²,Mfinanga Sayoki⁵,Phillips Patrick P. J.⁶,Gillespie Stephen H.⁷,Heysell Scott K.⁸,Sabiiti Wilber⁷,Mpagama Stellah G.¹²

Affiliation:

1. Kibong’oto Infectious Diseases Hospital (KIDH), Siha, Kilimanjaro, Tanzania

2. Department of Global Health and Biomedical Sciences, School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology (NM-AIST), Arusha, Tanzania

3. National Institute for Medical Research, Mbeya Medical Research Centre, Mbeya, Tanzania

4. Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana

5. National Institute for Medical Research, Muhimbili Centre, Dar Es Salaam, Tanzania

6. UCSF Center for Tuberculosis, University of San Francisco, San Francisco, California, USA

7. School of Medicine, University of St Andrews, St. Andrews, Scotland, United Kingdom

8. Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA

Abstract

Rifampin or multidrug-resistant tuberculosis (RR/MDR-TB) treatment has largely transitioned to regimens free of the injectable aminoglycoside component, despite the drug class’ purported bactericidal activity early in treatment. We tested whether Mycobacterium tuberculosis

Funder

DELTAS Africa Initiative

DELTA Africa Initiative

European and Developing Countries Clinical Trials Partnership

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02927-20

Reference50 articles.

1. Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method