Specificity of SARS-CoV-2 Antibody Detection Assays against S and N Proteins among Pre-COVID-19 Sera from Patients with Protozoan and Helminth Parasitic Infections

Author:

Yansouni Cedric P.1234ORCID,Papenburg Jesse3456,Cheng Matthew P.234,Corsini Rachel4,Caya Chelsea4,Vasquez Camargo Fabio7,Harrison Luke B.23,Zaharatos Gerasimos3,Büscher Philippe8,Faye Babacar9,Ndiaye Magatte9,Matlashewski Greg10ORCID,Ndao Momar24710

Affiliation:

1. J.D. MacLean Centre for Tropical Diseases, McGill University, Montreal, Quebec, Canada

2. Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada

3. Division of Microbiology, Department of Clinical Laboratory Medicine, Optilab Montreal – McGill University Health Centre, Montreal, Quebec, Canada

4. McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, Quebec, Canada

5. Division of Pediatric Infectious Diseases, Department of Pediatrics, Montreal Children’s Hospital, Montreal, Quebec, Canada

6. Department of Epidemiology, Biostatistics, and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, Canada

7. National Reference Centre for Parasitology, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

8. Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

9. Faculty of Medicine, Department of Parasitology, University of Cheikh Anta Diop, Dakar, Senegal

10. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

Abstract

We aimed to assess the specificity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody detection assays among people with tissue-borne parasitic infections. We tested three SARS-CoV-2 antibody-detection assays (cPass SARS-CoV-2 neutralization antibody detection kit [cPass], Abbott SARS-CoV-2 IgG assay [Abbott Architect], and Standard Q COVID-19 IgM/IgG combo rapid diagnostic test [SD RDT IgM/SD RDT IgG]) among 559 pre-COVID-19 seropositive sera for several parasitic infections.

Funder

McGill Interdisciplinary Initiative in Infection and Immunity

FRQ | Fonds de Recherche du Québec - Santé

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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