Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript-Reference-Cited by-同舟云学术

Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript

Published:2018-08-15 Issue:16 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ghanem Louis R.¹²³^ORCID,Kromer Andrew³,Silverman Ian M.³,Ji Xinjun³,Gazzara Matthew³,Nguyen Nhu³,Aguilar Gabrielle¹,Martinelli Massimo¹⁴,Barash Yoseph³,Liebhaber Stephen A.³⁵

Affiliation:

1. Gastroenterology, Hepatology and Nutrition Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

2. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy

5. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00175-18

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3. Yolk sac–derived primitive erythroblasts enucleate during mammalian embryogenesis