Affiliation:
1. Trudeau Institute, Saranac Lake, New York 12983
Abstract
Specific pathogen-free C57B1 mice are 100 to 1,000 times as sensitive as CD-1 mice to intravenous or oral challenge by
Salmonella enteritidis
or
S. gallinarum.
Resistance to infection by
S. pullorum
was unaffected. Growth of
Listeria monocytogenes
and
Mycobacterium bovis
(BCG) in intravenously infected C57B1 mice was similar to that seen in CD-1 mice. Quantitative counts of viable
S. enteritidis
in the walls of the stomach, small intestine, cecum, and large intestine and in the corresponding intestinal contents showed that most of the oral challenge inoculum was rapidly inactivated so that, by 24 hr, less than 1% was still viable. Overnight starvation and pretreatment with bicarbonate solution increased the relative survival of the challenge approximately 10-fold. Despite the rapid and extensive inactivation of the oral inoculum within the normal intestine, significant numbers of salmonellae reached the liver and spleen by 48 hr, and this systemic infection was subsequently responsible for the death of a high proportion of the challenged animals.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference30 articles.
1. Eflect of the normal microflora on the resistance of the small intestine;Abrams G. D.;J. Bacteriol.,1966
2. Resistance to Salmonella infections in inbred mouse strains;Boehme D. H.;Bull. N. Y. Acad. Med.,1970
3. Effect of specific immune mouse serum on the growth of Salmonella enteritidis in nonvaccinated mice challenged by various routes;Collins F. M.;J. Bacteriol.,1969
4. Immunity to enteric infection in mice;Collins F. M.;Infect. Immuniity,1970
5. Mechanisms in antimicrobial immunity;Collins F. M.;J. Reticuloendothel. Soc.,1971
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