Coxiella burnetii Plasmid Effector B Promotes LC3-II Accumulation and Contributes To Bacterial Virulence in a SCID Mouse Model-Reference-Cited by-同舟云学术

Coxiella burnetii Plasmid Effector B Promotes LC3-II Accumulation and Contributes To Bacterial Virulence in a SCID Mouse Model

Published:2022-06-16 Issue:6 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fu Mengjiao¹,Zhang Jianing¹,Zhao Mingliang¹,Zhang Shan¹,Dai Lupeng¹²,Ouyang Xuan¹,Yu Yonghui¹,Wen Bohai¹,Zhou Dongsheng¹^ORCID,Sun Yansong¹,Jiao Jun¹,Xiong Xiaolu¹^ORCID

Affiliation:

1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Fengtai, Beijing, People’s Republic of China

2. Anhui Medical University, Hefei, Anhui, China

Abstract

Coxiella burnetii , the causative agent of zoonotic Q fever, is characterized by replicating inside the lysosome-derived Coxiella -containing vacuole (CCV) in host cells. Some effector proteins secreted by C. burnetii have been reported to be involved in the manipulation of autophagy to facilitate the development of CCVs and bacterial replication.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00016-22

Reference58 articles.

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2. Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii

3. Q fever: the neglected biothreat agent