Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages-Reference-Cited by-同舟云学术

Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Santucci Pierre¹,Diomandé Sadia¹,Poncin Isabelle¹,Alibaud Laetitia²,Viljoen Albertus³,Kremer Laurent³⁴^ORCID,de Chastellier Chantal⁵,Canaan Stéphane¹^ORCID

Affiliation:

1. Aix-Marseille Univ, CNRS, LISM, IMM FR3479, Marseille, France

2. CNRS UMR5235, Université de Montpellier, Montpellier, France

3. Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS UMR9004, Montpellier, France

4. Inserm, IRIM, Montpellier, France

5. Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, Marseille, France

Abstract

Within tuberculous granulomas, a subpopulation of Mycobacterium tuberculosis resides inside foamy macrophages (FM) that contain abundant cytoplasmic lipid bodies (LB) filled with triacylglycerol (TAG). Upon fusion of LB with M. tuberculosis -containing phagosomes, TAG is hydrolyzed and reprocessed by the bacteria into their own lipids, which accumulate as intracytosolic lipid inclusions (ILI).

Funder

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

Institut National de la Santé et de la Recherche Médicale

Fondation pour la Recherche Médicale

Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche

Campus France

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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