Author:
Mancini Stefano,Laurent Frédéric,Veloso Tiago R.,Giddey Marlyse,Vouillamoz Jacques,Vandenesch François,Moreillon Philippe,Entenza José M.
Abstract
ABSTRACTMethicillin-resistantStaphylococcus aureus(MRSA) carrying themecCgene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptibleS. aureus(MSSA). We investigated whether at this temperature,mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five differentmecC-MRSA strains. These results suggest thatmecC-MRSA infections may successfully respond to treatment with β-lactams.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
4 articles.
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