Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence-Reference-Cited by-同舟云学术

Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence

Published:2021-04-16 Issue:5 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Smith Hans B.¹,Li Tin Lok²,Liao Man Kit²,Chen Grischa Y.¹,Guo Zhihong²,Sauer John-Demian¹^ORCID

Affiliation:

1. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA

2. Hong Kong Branch of Guangdong Southern Marine Science and Engineering Laboratory (Guangzhou), Shenzhen Research Institute and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong

Abstract

Listeria monocytogenes is a Gram-positive, intracellular pathogen that is highly adapted to invade and replicate in the cytosol of eukaryotic cells. Intermediate metabolites in the menaquinone biosynthesis pathway are essential for the cytosolic survival and virulence of L. monocytogenes , independent of the production of menaquinone (MK) and aerobic respiration.

Funder

Hong Kong Branch of Guangdong Southern Marine Science and Engineering Laboratory

HHS | National Institutes of Health

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00792-20

Reference48 articles.

1. The epidemiology of human listeriosis