Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA

Author:

Gaebler Christian1ORCID,Falcinelli Shane D.23ORCID,Stoffel Elina1,Read Jenna2,Murtagh Ross2,Oliveira Thiago Y.1,Ramos Victor1,Lorenzi Julio C. C.1,Kirchherr Jennifer2,James Katherine S.2,Allard Brigitte2,Baker Caroline2,Kuruc JoAnn D.24,Caskey Marina1,Archin Nancie M.24,Siliciano Robert F.56,Margolis David M.234ORCID,Nussenzweig Michel C.17ORCID

Affiliation:

1. Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA

2. UNC HIV Cure Center, University of North Carolina, Chapel Hill, North Carolina, USA

3. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA

4. Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA

5. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

6. Howard Hughes Medical Institute, Baltimore, Maryland, USA

7. Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA

Abstract

The intact proviral DNA assay (IPDA) and quadruplex PCR (Q4PCR) represent major advances in accurately quantifying and characterizing the replication-competent HIV reservoir. This study compares the two novel approaches for measuring intact HIV proviral DNA in samples from 39 antiretroviral therapy (ART)-suppressed people living with HIV, thereby informing ongoing efforts to deplete the HIV reservoir in cure-related trials.

Funder

HHS | National Institutes of Health

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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