Author:
Hagag N,Lacal J C,Graber M,Aaronson S,Viola M V
Abstract
Quiescent mouse NIH 3T3 cells responded to microinjection of activated ras p21 with a rapid and sustained rise in intracellular pH (approximately 0.17 pH units). The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter. Amiloride was found to suppress p21-induced mitosis, also.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
107 articles.
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