Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes-Reference-Cited by-同舟云学术

Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abdullahi Sa’ad T.¹²,Soyinka Julius O.¹^ORCID,Olagunju Adeniyi¹³^ORCID,Bolarinwa Rahman A.⁴,Olarewaju Olusola J.⁴,Bakare-Odunola Moji T.²,Winterberg Markus⁵⁶,Tarning Joel⁵⁶^ORCID,Owen Andrew³,Khoo Saye³^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria

2. Department of Pharmaceutical and Medicinal Chemistry, University of Ilorin, Ilorin, Nigeria

3. Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

4. Department of Haematology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria

5. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

6. Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Abstract

There is an increased recognition of the need to identify and quantify the impact of genetic polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of the pharmacokinetic drug-drug interaction between nevirapine and artemether-lumefantrine in HIV-positive and HIV-negative adult Nigerian subjects.

Funder

Novartis Pharma AG

HIV Research Trust

Bill and Melinda Gates Foundation

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00947-19

Reference56 articles.

1. World Health Organization. 2004. World health report 2004 statistical annex. World Health Organization, Geneva, Switzerland.

2. Is there an interaction between human immunodeficiency virus and Plasmodium falciparum?

3. The challenge of emerging and re-emerging infectious diseases

4. Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes in Southern African adults

5. World Health Organization. 2016. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. World Health Organization, Geneva, Switzerland.

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Association between CYP2B6 c.516G >T variant and acute leukaemia;Medicine;2021-08-13

2. The Manifesto of Pharmacoenosis: Merging HIV Pharmacology into Pathocoenosis and Syndemics in Developing Countries;Microorganisms;2021-07-31

3. CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy;Frontiers in Genetics;2021-07-12