Affiliation:
1. Department of Medicine, Division of Infectious Diseases, The George Washington University Medical Center, Washington, D.C. 20037
Abstract
Twenty strains of
Staphylococcus aureus
isolated from patients with endocarditis were examined in vitro for susceptibility to rifampin, nafcillin, and vancomycin and to combinations of rifampin with nafcillin or vancomycin. Minimum bactericidal concentrations of rifampin ranged from 0.0031 to 0.0125 μg/ml, of nafcillin ranged from 0.078 to 0.312 μg/ml, and of vancomycin ranged from 0.312 to 1.25 μg/ml. The combination of rifampin with nafcillin was synergistic for 12 strains; the combination of rifampin plus vancomycin was synergistic for 5 of the isolates.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference15 articles.
1. Antibiotic synergy in experimental infection with Pseudomonas. The effect ofcarbenicillin, cephalothin or cephanone combined with tobramycin or gentamicin;Andriole V. T.;J. Infect. Dis.,1974
2. Synergistic effects of oleandomycin and rifampin SV in experimental staphylococcal septicemia in rabbits;Banic S.;Infect. Immun.,1974
3. Therapy of experimental staphylococcal infections with antibiotic combinations;Campos M. E.;J. Lab. Clin. Med.,1974
4. Successful treatment of S. aureus endocarditis with vancomycin and rifampin following previous treatment failure;Faville E. J.;J. Am. Med. Assoc., in press.,1978
5. Bacteriologic studies in rifampin, a new semi-synthetic antibiotic;Kunin C. M.;J. Infect. Dis.,1969
Cited by
82 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献