Affiliation:
1. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206
Abstract
Clinically isolated strains ofStaphylococcus aureusthat are inducibly resistant to both erythromycin and penicillin were susceptible to a combination of the two antibiotics. The synergistic effect of the combination results from an inhibition of penicillinase induction by erythromycin, sparing penicillin and allowing this drug to inhibit growth. When resistance to erythromycin is constitutive rather than inducible, the combination is no longer synergistic.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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