Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis-Reference-Cited by-同舟云学术

Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis

Published:2007-01 Issue:1 Volume:75 Page:508-511
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bozue J.¹,Cote C. K.¹,Moody K. L.¹,Welkos S. L.¹

Affiliation:

1. Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702

Abstract

ABSTRACT The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant ( bclA ) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01202-06

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