eIF4A3 Promotes RNA Viruses’ Replication by Inhibiting Innate Immune Responses

Author:

Gao Qingxia1,Jiang Meijun1,Zhao Yaxin1,Li Guoli1,Yang Cha1,Ren Caiyue1,Jin Meilin12ORCID,Chen Huanchun12,Zhou Hongbo12ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People’s Republic of China

2. Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, People’s Republic of China

Abstract

Production of type I IFN is pivotal for the cellular antiviral immunity. Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I IFN to eliminate viral infection.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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