Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC

Author:

Kibler Karen V.1,Asbach Benedikt2,Perdiguero Beatriz3,García-Arriaza Juan3,Yates Nicole L.4,Parks Robert4,Stanfield-Oakley Sherry4,Ferrari Guido4,Montefiori David C.4,Tomaras Georgia D.4,Roederer Mario5,Foulds Kathryn E.5,Forthal Donald N.6,Seaman Michael S.7,Self Steve8,Gottardo Raphael8,Phogat Sanjay9,Tartaglia James9,Barnett Susan10,Cristillo Anthony D.11,Weiss Deborah11,Galmin Lindsey11,Ding Song12,Heeney Jonathan L.13,Esteban Mariano3,Wagner Ralf214,Pantaleo Giuseppe15,Jacobs Bertram L.116

Affiliation:

1. Biodesign Institute, Arizona State University, Tempe, Arizona, USA

2. Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

3. Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain

4. Duke University Medical Center, Durham, North Carolina, USA

5. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

6. Division of Infectious Diseases Department of Medicine, University of California, Irvine School of Medicine, Irvine, California, USA

7. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

8. Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

9. Sanofi Pasteur, Swiftwater, Pennsylvania, USA

10. Novartis Vaccines and Diagnostics, Inc., Cambridge, Massachusetts, USA

11. Advanced BioScience Laboratories, Inc., Rockville, Maryland, USA

12. EuroVacc Foundation, Lausanne, Switzerland

13. Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

14. Institute of Clinical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

15. Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland

16. School of Life Sciences, Arizona State University, Tempe, Arizona, USA

Abstract

Though the RV144 phase III clinical trial showed promise that an effective vaccine against HIV-1 is possible, a successful vaccine will require improvement over the vaccine candidate (ALVAC) used in the RV144 study. With that goal in mind, we have tested in nonhuman primates an attenuated but replication-competent vector, NYVAC-KC, in direct comparison to its parental vector, NYVAC, which is replication restricted in human cells, similar to the ALVAC vector used in RV144. We have utilized a prime-boost regimen for administration of the vaccine candidate that is similar to the one used in the RV144 study. The results of this study indicate that a replication-competent poxvirus vector may improve upon the effectiveness of the RV144 clinical trial vaccine candidate.

Funder

DAIDS-NIAID-NIH

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference54 articles.

1. Moss B. 1996. Poxviridae: the viruses and their replication, p 2637–2671. In Fields BN, Knipe DM, Howley PM, Chanock RM, Melnick JL, Monath TP, Roizman R, Straus SE (ed), Fields virology, 3rd ed, vol 2. Lippincott-Raven, Philadelphia, PA.

2. Applications of pox virus vectors to vaccination: an update.

3. Safe and effective poxvirus vectors–NYVAC and ALVAC;Paoletti E;Dev Biol Stand,1994

4. Clinical applications of attenuated MVA poxvirus strain

5. Poxvirus-based vaccine candidates for HIV: two decades of experience with special emphasis on canarypox vectors

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3