Pak4 Induces Premature Senescence via a Pathway Requiring p16 INK4 /p19 ARF and Mitogen-Activated Protein Kinase Signaling
Author:
Affiliation:
1. Columbia University, Biological Sciences MC 2460, Sherman Fairchild Center, Room 813, 1212 Amsterdam Ave., New York, New York 10027
Abstract
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Link
https://journals.asm.org/doi/pdf/10.1128/MCB.25.21.9532-9542.2005
Reference48 articles.
1. Abo, A., J. Qu, M. S. Cammarano, C. Dan, A. Fritsch, V. Baud, B. Belisle, and A. Minden. 1998. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J. 17 : 6527-6540.
2. Alani, R. M., A. Z. Young, and C. B. Shifflett. 2001. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a. Proc. Natl. Acad. Sci. USA 98 : 7812-7816.
3. Bagrodia, S., and R. A. Cerione. 1999. PAK to the future. Trends Cell Biol. 9 : 350-355.
4. Bishop, A. L., and A. Hall. 2000. Rho GTPase and their effector proteins. Biochem. J. 348 : 241-255.
5. Bringold, F., and M. Serrano. 2000. Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol. 35 : 317-329.
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