Identification of Babesia bigemina and Babesia bovis merozoite proteins with isolate- and species-common epitopes recognized by antibodies in bovine immune sera

Author:

McElwain T F1,Palmer G H1,Goff W L1,McGuire T C1

Affiliation:

1. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.

Abstract

Immunoprecipitation of radiolabeled antigens with bovine antisera indicated that many Babesia bigemina and Babesia bovis merozoite proteins contain isolate-common epitopes, while at least 16 B. bigemina and 8 B. bovis proteins contain species-cross-reactive epitopes. One immunogenic, isolate-common, and species-specific candidate diagnostic protein from each species was identified.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference22 articles.

1. DNA polymorphisms and subpopulations in Babesia bovis;Cowman A. F.;Mol. Biochem. Parasitol.,1984

2. Development of a highly infective Babesia bigemina vaccine of reduced virulence;Dalgliesh R. J.;Aust. Vet. J.,1981

3. Babesia bigemina vaccine: comparison of the efficacy and safety of Australian and South African strains under experimental conditions in South Africa;De Vos A. J.;Onderstepoort J. Vet. Res.,1982

4. Babesia bovis: increased percentage parasitized erythrocytes in cultures and assessment of growth by incorporation of [3H]hypoxanthine;Goff W. L.;Exp. Parasitol.,1986

5. Preparation and preliminary assessment of purified antigens in the passive haemagglutination test for bovine babesiosis;Goodger B. V.;Aust. Vet. J.,1971

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