The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF- κ B-Reference-Cited by-同舟云学术

The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF- κ B

Published:2021-02-23 Issue:3 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Khalil Jumana¹²,Yamada Shintaro³,Tsukamoto Yuta³,Abe Hiroto¹²,Shimojima Masayuki⁴,Kato Hiroki¹³,Fujita Takashi¹²^ORCID

Affiliation:

1. Laboratory of Virus Immunology, Institute for Frontier Life and Medical Science, Kyoto University, Kyoto, Japan

2. Laboratory of Molecular and Cellular Immunology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

3. Institute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany

4. Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging highly pathogenic phlebovirus. The syndrome is characterized by the substantial production of inflammatory cytokines and chemokines, described as a cytokine storm, which correlates with multiorgan failure and high mortality.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00542-20

Reference50 articles.

1. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China

2. Metagenomic Analysis of Fever, Thrombocytopenia and Leukopenia Syndrome (FTLS) in Henan Province, China: Discovery of a New Bunyavirus