Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci-Reference-Cited by-同舟云学术

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci

Published:1992-04 Issue:4 Volume:36 Page:867-869
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arthur M¹,Molinas C¹,Bugg T D¹,Wright G D¹,Walsh C T¹,Courvalin P¹

Affiliation:

1. Unité des Agents Antibactériens, Institut Pasteur, Paris, France.

Abstract

The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore appears to be a substrate of VanA in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.36.4.867

Reference14 articles.

1. Arthur M. C. Molinas and P. Courvalin. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. in press.

2. Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases;Arthur M.;Gene,1991

3. Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity;Bugg T. D. H.;Biochemistry,1991

4. Molecular basis for vancomycin resistance in Enterococcusfaecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA;Bugg T. D. H.;Biochemistry,1991

5. The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes;Dutka-Malen S.;Mol. Gen. Genet.,1990

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