In vitro antistaphylococcal activity and testing of RP 59500, a new streptogramin, by two methods-Reference-Cited by-同舟云学术

In vitro antistaphylococcal activity and testing of RP 59500, a new streptogramin, by two methods

Published:1992-04 Issue:4 Volume:36 Page:854-855
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Aldridge K E¹,Schiro D D¹,Varner L M¹

Affiliation:

1. Louisiana State University Medical Center, New Orleans 70112.

Abstract

The in vitro antistaphylococcal activity of RP 59500, a new streptogramin, was comparable to those of vancomycin and teicoplanin against Staphylococcus aureus, and RP 59500 was the most active agent against coagulase-negative staphylococci. All staphylococcal strains were inhibited by 4 micrograms of RP 59500 per ml, including multiply resistant strains. Broth microdilution and agar dilution testing gave comparable results in 97% of the tests with RP 59500.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.36.4.854

Reference5 articles.

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3. Bernard E. J. Entenza H. Etesse D. H. Bouanchaud and P. Dellamonica. 1991. Interstitial fluid diffusion of RP59500 in a rabbit tissue cage model. Program Abstr. 31st Intersci. Conf. Antimicrob. Agents Chemother. abstr. 903.

4. In vitro activity of RP 59500, a semisynthetic injectable pristinamycin, against staphylococci, streptococci, and enterococci;Fass R. J.;Antimicrob. Agents Chemother.,1991

5. National Committee for Clinical Laboratory Standards. 1990. Approved standard M7-A2. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. National Committee for Clinical Laboratory Standards Villanova Pa.

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