Immunomodulatory Effects of Lactobacillus plantarum on Inflammatory Response Induced by Klebsiella pneumoniae

Author:

Vareille-Delarbre Marjolaine1,Miquel Sylvie2,Garcin Sophie1,Bertran Thomas1,Balestrino Damien2ORCID,Evrard Bertrand13,Forestier Christiane2

Affiliation:

1. Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, Laboratoire d’Immunologie, Clermont-Ferrand, France

2. Université Clermont Auvergne, UMR CNRS 6023 LMGE, Laboratoire de Bactériologie, Clermont-Ferrand, France

3. CHU Clermont-Ferrand, Service d’Immunologie, Clermont-Ferrand, France

Abstract

Some respiratory infections have been associated with dysbiosis of the intestinal microbiota. The underlying mechanism is incompletely understood, but cross talk between the intestinal microbiota and local immune cells could influence the immune response at distal mucosal sites. This has led to the concept of enhancing respiratory defenses by modulating the intestinal microbiota with exogenous supplementation of beneficial strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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