Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence-Reference-Cited by-同舟云学术

Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence

Published:2020-11-16 Issue:12 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Duprilot Marion¹²,Baron Alexandra¹,Blanquart François¹³,Dion Sara¹,Pouget Cassandra⁴,Lettéron Philippe⁵,Flament-Simon Saskia-Camille⁶,Clermont Olivier¹,Denamur Erick¹⁷^ORCID,Nicolas-Chanoine Marie-Hélène¹^ORCID

Affiliation:

1. Université de Paris, INSERM, IAME, Paris, France

2. AP-HP, Laboratoire de Microbiologie, Hôpital Beaujon, Clichy, France

3. Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France

4. VBMI, INSERM U1047, Université de Montpellier, Nîmes, France

5. Université de Paris, UMR 1149, INSERM-ERL, CNRS 8252, Paris, France

6. Laboratorio de Referencia de Escherichia coli (LREC), Departamento de Microbioloxía e Parasitoloxía, Facultade de Veterinaria, Universidade de Santiago de Compostela (USC), Lugo, Spain

7. AP-HP, Laboratoire de Génétique Moléculaire, Hôpital Bichat, Paris, France

Abstract

Escherichia coli O25b:H4 sequence type 131 (ST131), which is resistant to fluoroquinolones and which is a producer of CTX-M-15, is globally one of the major extraintestinal pathogenic E. coli (ExPEC) lineages. Phylogenetic analyses showed that multidrug-resistant ST131 strains belong to clade C, which recently emerged from clade B by stepwise evolution. It has been hypothesized that features other than multidrug resistance could contribute to this dissemination since other major global ExPEC lineages (ST73 and ST95) are mostly antibiotic susceptible.

Funder

Fondation de la Recherche Médicale

Spanish Ministerio de Educacion

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00576-20

Reference56 articles.

1. The Epidemic of Extended-Spectrum-β-Lactamase-Producing Escherichia coli ST131 Is Driven by a Single Highly Pathogenic Subclone, H 30-Rx