Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147-Reference-Cited by-同舟云学术

Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147

Published:2022-01-11 Issue:1 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Prado-Alonso Laura¹²³,Pérez-Victoria Ignacio⁴,Malmierca Mónica G.¹²³,Montero Ignacio¹²³,Rioja-Blanco Elisa¹,Martín Jesús⁴,Reyes Fernando⁴,Méndez Carmen¹²³,Salas José A.¹²³,Olano Carlos¹²³^ORCID

Affiliation:

1. Departamento de Biología Funcional, Universidad de Oviedo, Oviedo (Asturias), Spain

2. Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, Oviedo (Asturias), Spain

3. Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo (Asturias), Spain

4. Fundación MEDINA, Parque Tecnológico de Ciencias de la Salud, Granada, Spain

Abstract

Genome mining has proven its usefulness in the search for novel bioactive compounds produced by microorganisms, and halogenases comprise an interesting starting point. In this work, we have identified a new halogenase coding gene that led to the discovery of novel lipopetide nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS)-derived natural products, the colibrimycins, produced by Streptomyces sp. strain CS147, isolated from the Attini ant niche.

Funder

Ministerio de Ciencia, Innovación y Universidades

Ministerio de Economía, Industria y Competitividad, Gobierno de España

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01839-21

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