Evaluation of 500- and 1,000-mg doses of ciprofloxacin for the treatment of chancroid

Author:

Bodhidatta L1,Taylor D N1,Chitwarakorn A1,Kuvanont K1,Echeverria P1

Affiliation:

1. Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Abstract

A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg (500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 micrograms/ml (range, 0.002 to 0.03 micrograms/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference12 articles.

1. Chancroid: a report of 1402 cases;Asin J.;Am. J. Syphilis Gonorrhea Vener. Dis.,1952

2. Treatment of chancroid with erythromycin;Carpenter J. L.;Sex. Transm. Dis.,1981

3. Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin;Crider S. R.;N. Engl. J. Med.,1984

4. Treatment of chancroid with erythromycin: a clinical and a microbiological appraisal;Duncan M. O.;Br. J. Vener. Dis.,1983

5. Clinical evaluation of rosoxacin for the treatment of chancroid;Haase D. A.;Antimicrob. Agents Chemother.,1986

Cited by 26 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3