Animal model for evaluating the convulsive liability of beta-lactam antibiotics-Reference-Cited by-同舟云学术

Animal model for evaluating the convulsive liability of beta-lactam antibiotics

Published:1988-05 Issue:5 Volume:32 Page:758-760
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Williams P D¹,Bennett D B¹,Comereski C R¹

Affiliation:

1. Department of Experimental Toxicology, Bristol-Myers Company, Syracuse, New York 13221-4755.

Abstract

The beta-lactam antibiotics imipenem-cilastatin, BMY-26225, and cefazolin significantly lowered the convulsive threshold of pentylenetetrazole in mice. In addition, imipenem-cilastatin and cefazolin were found to inhibit 3H-labeled gamma-aminobutyric acid binding to synaptic membranes from rat brains. Our results suggest that the pentylenetetrazole convulsive model may be useful in evaluating the proconvulsive liabilities of new carbapenems and other beta-lactam antibiotics and that the mechanism of imipenem-cilastatin and cefazolin toxicity may involve interaction with gamma-aminobutyric acid receptors.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.32.5.758

Reference19 articles.

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