Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus-Reference-Cited by-同舟云学术

Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus

Published:2005-02 Issue:3 Volume:79 Page:1966-1969
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Åkerström Sara¹,Mousavi-Jazi Mehrdad²,Klingström Jonas¹³,Leijon Mikael²,Lundkvist Åke¹³,Mirazimi Ali¹

Affiliation:

1. Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control, Solna

2. LightUp Technologies, Huddinge

3. MTC/Karolinska Institutet, Stockholm, Sweden

Abstract

ABSTRACT Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S -nitroso- N -acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.3.1966-1969.2005

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