Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands-Reference-Cited by-同舟云学术

Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

Published:2013-03-15 Issue:6 Volume:87 Page:3592-3596
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Handke Wiebke¹,Luig Christina¹,Popović Branka²,Krmpotić Astrid²,Jonjić Stipan²,Brune Wolfram¹

Affiliation:

1. Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany

2. Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

Abstract

ABSTRACT Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1 −/− mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo .

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02657-12

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